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Professor Khakoo is a leading researcher in Hepatology and an active clinician whose work has focused on natural killer (NK) cells and their receptors in the context of human diseases. His research group has been instrumental in uncovering the genetic variation of killer-cell immunoglobulin-like receptors (KIRs) and their interactions with HLA class molecules, which shape immune responses. The group has demonstrated how these interactions affect the outcome of hepatitis C virus infection, providing a foundation for immunogenetic approaches to liver diseases. He has published extensively in high-impact journals and collaborates widely across immunology, virology, and hepatology. His work integrates molecular immunology with translational research, aiming to harness NK cells for therapeutic interventions in diseases. Currently, he is developing NK cell-based interventions for hepatocellular carcinoma, the most common cancer killer worldwide, while also working on projects related to metabolism-associated steatotic liver disease, pregnancy-related disorders, and viral infections.