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Sallie (Penny) W. Chisholm is a distinguished Institute Professor at the Massachusetts Institute of Technology, specializing in the biology, ecology, and evolution of marine phytoplankton. Her research primarily focuses on understanding the forces that shape microbial ecosystems, particularly studying the cyanobacterium Prochlorococcus, the smallest and most abundant microbe in ocean ecosystems, which accounts for half of the total photosynthetic biomass. Chisholm employs a model system to investigate life from the genome to the ecosystem scale, aiming to grasp the ecology and evolution of ocean microbes and their influence on global biogeochemical cycles. Over her career, she has been recognized with numerous prestigious awards for her contributions to science, including the Crafoord Prize in 2019 and the Ramon Margalef Prize in Ecology in 2013.