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The Peng Laboratory develops optical imaging techniques and nanoprobes that enable long-term single-molecule imaging of living systems, revealing the molecular interactions responsible for human diseases. The multidisciplinary research in the Peng group aims to elucidate the molecular mechanisms by which human diseases occur. The lab integrates a diverse toolbox spanning single-molecule microscopy, super-resolution microscopy, spectroscopy, nanomaterial engineering, biophysics, chemical biology, and quantitative modeling to uncover previously unexplored biological processes. With bright photostable probes, we possess the unprecedented capability to record ultralong-term 'molecular movies' in living systems at high spatiotemporal resolutions, which reveal the molecular interactions that drive biological functions. The research is particularly focused on studying molecular dynamics, protein-protein interactions, and cellular heterogeneity involved in neurobiology and cancer biology.
Massachusetts Institute of Technology • Cambridge, MA
Core Institute Member, Broad Institute of MIT and Harvard.