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Sam Sheppard is a Research Fellow in the Department of Life Sciences at Imperial College London. His research focuses on Natural Killer (NK) cells, which are innate immune cells that secrete inflammatory cytokines and kill infected or cancerous cells. NK cells are vital for optimal immunosurveillance of cancer cells. Initial results from NK cell-based therapeutic trials for leukemia have shown promise; however, targeting solid tumors with NK cell-based therapies has proven to be more challenging. Solid tumors are thought to create nutrient-limited environments that alter immune cell functionality. To address these challenges, Sheppard employs super-resolution microscopy and metabolomics to study novel mechanisms that influence NK cell functionality based on environmental factors. His work aims to discover methods to therapeutically enhance NK cell function in cancer and NK cell-sensitive diseases.
Specialisms available in Materials for the Energy Transition or Theory and Simulation of Materials.