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Sam Thiagalingam is an Associate Professor at Boston University Chobanian & Avedisian School of Medicine, specializing in Biomedical Genetics. He earned his PhD from Johns Hopkins University and has a robust background in cancer genetics, with specific research interests in SMAD4 inactivation and its critical role in the late stages of colon cancer progression. He leads a research team that has identified several novel SMAD genes and proposed a multi-modular molecular network model for understanding cancer progression and metastasis. His lab studies the required signaling pathways for sustaining 'epigenetic memory', a crucial aspect in the epithelial-mesenchymal transition (EMT). In addition to his cancer research, Thiagalingam is interested in the epigenomics of complex diseases, including schizophrenia and bipolar disorder, focusing on genetic determinants that affect these conditions. His work aims to correlate epigenomic alterations with disease pathogenesis while identifying therapeutic targets. As a mentor to graduate students at Boston University, he actively engages in educating the next generation of researchers in the field of genetics and interdisciplinary biomedical research through initiatives at the Evans Center and the Boston University-Boston Medical Center Cancer Center.
Boston University Chobanian & Avedisian School of Medicine • Boston, MA
Conducting research in cancer genetics, focusing on SMAD4 and its implications in colon cancer, while mentoring graduate students.
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