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Samuel Dudley is an Adjunct Professor in the Department of Medicine at the Warren Alpert Medical School of Brown University in Providence, Rhode Island. His research primarily focuses on cardiovascular diseases, particularly the fundamental mechanisms that underlie arrhythmias and cardiomyopathy. His laboratory explores various aspects of cardiac function, including transcriptional and post-translational regulation of sodium channels, as well as the impact of redox-sensitive pathways on Ca2+ handling in heart failure. One of Dudley's significant contributions is highlighting the role of alternative splicing in cardiac sodium channel regulation in human heart failure. He has demonstrated that various splicing regulators are upregulated in heart failure models, which could play a crucial role in arrhythmic risk. His work utilizes advanced genetic models and biochemical approaches to elucidate the connections between cardiac signaling pathways and arrhythmogenesis. Over the years, Dudley has received numerous grants to support his innovative research, including substantial funding from the National Institutes of Health. He also actively contributes to the academic community as a reviewer for several prestigious journals and has served on various editorial and advisory boards, focusing on cardiovascular health and electrophysiology.
Department: Department of Economics