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Dr. Samuel C. Silverstein is the Emeritus John C. Dalton Professor in the Department of Physiology & Cellular Biophysics at Columbia University, where he has made significant contributions to the understanding of immune cell dynamics and cellular immunotherapy. His research primarily focuses on the functions of polymorphonuclear neutrophils, mononuclear phagocytes, lymphocytes, and platelets in innate immunity and disease processes. He has developed a quantitative model of cellular immunotherapy that elucidates the mechanisms by which CD8+ T-cells mediate the destruction of target cells, particularly in the context of neoplastic and infectious diseases. This model integrates experimentally derived equations that describe neutrophil bactericidal activity, which advances the understanding of how CD8+ T-cells can be activated and their efficiency enhanced in a therapeutic setting. In addition to his research, Dr. Silverstein has been deeply involved in science education, leading programs that focus on improving the quality of secondary science education in public schools. His involvement with Columbia University’s Summer Research Program for Science Teachers has significantly impacted science teachers and their students, promoting hands-on laboratory research and enhancing teaching methodologies.
Department of Anthropology (GSAS)