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Sandra Davidge's laboratory studies cardiovascular physiology with a specific interest in women’s, maternal, and perinatal cardiovascular health. Her research investigates the potential mediators of vascular endothelial cell dysfunction in pregnancy complications such as preeclampsia. She aims to understand the impact of pregnancy complications on the long-term cardiovascular health of offspring born to adverse intrauterine environments, a concept known as the developmental origins of disease. Davidge's work addresses the mechanisms of normal cardiovascular adaptations during pregnancy and the impaired vascular responses experienced by women with preeclampsia, a disorder characterized by hypertension and proteinuria. Additionally, she examines the effect of oxidative stress on endothelial cell function as a potential mechanism for vascular dysfunction in these women. Her lab is committed to training undergraduate and graduate students as well as post-doctoral fellows. The research is supported by various organizations including the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada.
Department: Mechanical Engineering and Engineering Management