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Sandra Hofmann is an Associate Professor in Bioengineering focused on the Orthopaedic Biomechanics research group at Eindhoven University of Technology. Her current research centers on the bioengineering of skeletal tissues, particularly bone. She emphasizes the visualization and understanding of how cells respond to environmental factors (chemical, mechanical, and cellular) using tissue-engineered in vitro models of bone tissue. Bone diseases present a multifaceted challenge with a significant impact on individuals and society, especially with the aging population facing increasing incidence of skeletal issues. This research aims to develop a human cell-based functional 3D in vitro model of bone to study the interactions between different cell types derived from human donors, whether healthy or diseased, young or aged. Her work also involves the use of bioreactors developed for longitudinal imaging of the mineralized extracellular matrix development of cells, employing micro-computed tomography and computational approaches to describe environments and predict tissue formation in vitro. She is recognized for her efforts to engineer bone through innovative approaches that maintain health while preventing disease.
Eindhoven University of Technology • Eindhoven, Netherlands
Leading research in Orthopaedic Biomechanics and Bioengineering.
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