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Sandro Mecozzi's research efforts focus on fundamental studies of non-covalent interactions and their applications in solving biochemical and biomedical problems. His work employs advanced computational techniques in conjunction with chemical synthesis to generate molecules capable of recognizing intermolecular forces. Among his key areas of study are the nature of specific intermolecular forces in condensed phases and the peculiar behavior of highly fluorinated materials in interaction with small molecules and short RNAs. Mecozzi has explored the concept of the fluorous phase, where the introduction of fluorine substituents radically alters a molecule's physicochemical properties. He has contributed to the development of high-performance materials and drug delivery systems by synthesizing innovative semifluorinated di- and triblock copolymers. His research also focuses on short RNA-small molecule complexes aiming to design RNA sequences that can bind small organic compounds with high selectivity and affinity. With a strong educational background, he has worked in esteemed institutions and continues to conduct significant research in the field of molecular recognition and non-covalent forces.
University of Wisconsin-Madison • Madison, WI
Joined the faculty of the Division of Pharmaceutical Sciences, holding joint appointments in Pharmacy and Chemistry.
Department: Department of Computer Sciences