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Sanduni Jayakodi is a PhD student at Umeå University, working in Anders Olofsson's lab at the Department of Clinical Microbiology. Her research focuses on understanding the molecular mechanisms underlying protein misfolding diseases, particularly transthyretin (TTR) amyloidosis. In a recent study published in the Journal of Biological Chemistry, she investigated how the redox environment and macromolecular crowding influence TTR misfolding in vivo. The study discovered the formation of non-native pathological TTR species in plasma TTR-Val30Met gene carriers, where oxidative conditions suppressed reducing agents and inhibited misfolding. This research suggests that local protein concentration and environmental factors play crucial roles in TTR stability. Additionally, she is a co-inventor of the Swedish patent (SE2350342A1), which proposes a novel redox-based strategy to prevent reverse TTR aggregation using thiol- and disulfide-modifying agents like N-acetylcysteine. Sanduni's interdisciplinary work aims to deepen the understanding of molecular disease mechanisms and support the development of novel, cost-effective therapeutic approaches.
A strategy to prevent reverse TTR aggregation using thiol- and disulfide-modifying agents such as N-acetylcysteine.
Requirements are standard for Master's programs across Social Sciences and Humanities at Umeå. English 6 proficiency is the general rule.