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Dr. Sanghyun Lee has dedicated his scientific career to dissecting host-virus interactions at the molecular physiological levels, aiming to understand how these interactions contribute to viral pathogenesis. He earned his Ph.D. from Seoul National University in Korea, focusing on the role of viral non-coding RNAs in the virulence of human cytomegalovirus. After his doctoral training, he pursued postdoctoral research at Washington University in St. Louis, in the labs of Skip Virgin and Megan Baldridge, where he investigated the cellular tropism of norovirus and the role of interferon-lambda in immune control of the intestine. In 2020, Dr. Lee established an independent research program at Brown University, where his group actively explores novel host-virus interactions with the goal of developing vaccines and therapeutics for enteric viruses and coronaviruses. His main research focus involves understanding dynamic host-virus interactions within cells and animals, examining how hosts control viral infections and how viruses counteract host immune responses. He utilizes mouse models with various knockout and knock-in lines to study viral pathogenesis and employs unbiased screening techniques using CRISPR technologies to discover novel anti-viral and pro-viral cellular genes.
Brown University • Providence, RI, USA
Establishing an independent research program focusing on host-virus interactions.
Department: Department of Economics