Dr. Sangram Sisodia

Biography

Sangram S. Sisodia is the Thomas Reynolds Sr. Family Professor at the University of Chicago, specializing in Neurobiology within the Biological Sciences Division. With a focus on Alzheimer's disease, his laboratory investigates the cellular and molecular biology of amyloid precursor protein (APP) and its associated proteins. Since the past 20 years, Sisodia's research has elucidated the mechanisms behind the pathophysiology of Alzheimer's disease, addressing both genetic and environmental factors influencing amyloid metabolism and deposition. Notably, his collaborative work has reinforced the role of synaptic activity in APP processing and its implications for neurodegeneration. The lab's current efforts concentrate on understanding APP trafficking, processing in cultured neurons, and how mutations in presenilins affect neuronal vulnerability. Recent studies in Sisodia's lab explore the intricate relationships between the gut microbiome and amyloid pathology, aiming to integrate genetic information with neurobiological insights to provide a deeper understanding of therapeutic avenues. His contributions to the field are recognized through numerous publications, shedding light on cellular interactions and the potential for mechanism-based treatments for Alzheimer's disease.

Research Interests

Experience