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Dr. Sangram S. Sisodia is a prominent neurobiologist and the Thomas Reynolds Sr. Family Professor in the Department of Neurology at the University of Chicago. His research focuses on Alzheimer’s disease, an adult-onset neurodegenerative disease characterized by cognitive decline and pathological changes in the brain. Over the past two decades, Dr. Sisodia has concentrated on the cellular and molecular biology of the amyloid precursor protein (APP) and the presenilins (PS1 and PS2), which are key genetic components of familial forms of Alzheimer’s disease. His work has significantly advanced the understanding of APP processing and its implications for Alzheimer’s pathophysiology, particularly in the role of synaptic activity modulating amyloid beta production. His laboratory employs innovative approaches such as live-cell imaging and gene targeting strategies to unravel the mechanisms underlying Alzheimer’s disease and has developed transgenic animal models to study FAD-linked mutations. Future research initiatives are set to investigate the complex interactions between genetic factors and environmental influences, such as the role of gut microbiome in Alzheimer’s disease progression. His contributions have opened pathways for potential therapeutic strategies aimed at combating this devastating condition.
Department of Philosophy