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Sara Prescott investigates sensory inputs that control mammalian physiology and behavior. Her research focuses on how the cells lining airways communicate with sensory neurons in response to chemical and mechanical signals, evoking vital reflexes like coughing. This cellular collaboration protects the airways from damage and stabilizes breathing but can become dysregulated in disease, presenting fundamental questions regarding sensory transduction. Using mammalian airways as a model system, Prescott aims to investigate how physiological insults are detected and addressed by essential barrier tissues, with the ultimate goal of providing new therapeutic approaches for autonomic dysfunction.