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Professor Sarah Bray is a leading researcher in the field of developmental biology at the University of Cambridge, where she heads a laboratory focused on understanding the complex dynamics of cell signaling pathways, particularly the Notch pathway, which plays a crucial role in coordinating animal development. Her interdisciplinary research integrates live imaging, genetic, biochemical, and genomic approaches using both Drosophila and human cells. The laboratory aims to decode the regulatory dynamics of stem cell behavior and tissue organization after Notch signaling activation, a process critical in normal development and disease contexts like cancer and dementia. Bray's work addresses essential questions regarding the epigenetic mechanisms that reset transcriptional responses as cells transition states, exploring the role of chromatin remodeling complexes and enhancer-promoter interactions. The implications of her findings extend to informing targeted therapeutic strategies for diseases linked to aberrant Notch signaling, making her contributions vital in the field of developmental biology.
University of Cambridge • Cambridge
Leading research focusing on the Notch signaling pathway and its implications in developmental biology.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.