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Professor Sarah Bray is affiliated with the Cambridge Stem Cell Institute. Her research focuses on the regulatory dynamics of the Notch signaling pathway in stem cells and how these mechanisms affect development and disease. Bray's work aims to elucidate how cells organize into tissues and maintain homeostasis through precise cellular signaling. She employs a combination of live imaging, genetic, biochemical, and genomic methods in both Drosophila and human cells to uncover fundamental mechanisms that reset and sculpt transcriptional responses to Notch signaling. Her current investigations include questions about enhancer communication, epigenetic resets during cellular transitions, and the influence of tissue geometry on signaling dynamics. Bray aims to contribute to the understanding of aberrant Notch function in diseases, including dementia and cancers, which informs strategies for targeted therapies.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.