Generate a tailored SOP for Dr. Sarah De Val. Improve your application with a focused, well-structured draft.
Sarah De Val is a researcher in the Department of Physiology, Anatomy and Genetics at the University of Oxford. Her work focuses on developing novel strategies to modulate vessel growth, particularly in the context of ischemic heart disease and the challenges associated with existing therapeutic options. Throughout her career, she has investigated aspects of gene regulation with a specific emphasis on transcriptional pathways that govern dynamic gene expression patterns essential for the proper formation and function of the mammalian vascular system. Her post-doctoral research involved the analysis of gene enhancers and transgenic mouse models to describe the transcriptional pathways regulating endothelial cell specification. As an independent researcher, she aims to further understand the regulatory mechanisms that control angiogenesis and vascular differentiation, taking an enhancer-centric approach. Her recent investigations include the SOXF/NOTCH regulatory pathway and the VEGFA-MEF2 pathway's role in angiogenic endothelial cell behavior. She utilizes zebrafish and mouse models to leverage advanced techniques such as visualization and genome engineering for studying these pathways in pathological conditions. Her research is supported by grants and fellowships from various prestigious organizations.
Department of Politics and International Relations - Higher Level English requirement.