Professor Dr. Sarah Johnstone

Biography

Sarah Johnstone is an Assistant Professor of Pathology at Harvard University, specializing in the Biological Biomedical Sciences PhD program. Her lab, the Johnstone Lab, is dedicated to studying the molecular mechanisms underlying nuclear organization in cancer. The research focuses on epigenetic and topological packaging of the genome and its implications for transcription in tumor cell phenotypes. The lab employs advanced genomic techniques, imaging, and analytical tools to investigate chromatin structure and its alterations in cancer. Current projects explore the effects of DNA hypomethylation on the 3D genome, deep mapping of nuclear changes in cancer models, and the structural impacts of mutations in core factors like CTCF. Johnstone’s work closely integrates computational approaches and omics analyses to enhance the understanding of cancer biology at a molecular level.

Research Interests

Experience