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Sarah Lummis is a researcher in the Department of Biochemistry with a specific focus on the characterization of Cys-loop receptors. The Cys-loop pentameric ligand-gated ion channel (pLGIC) family includes neurotransmitter-gated channels that facilitate rapid signal transmission at neuronal synapses. Dysfunction in these receptors has been implicated in a range of neurological disorders including epilepsy, schizophrenia, and drug addiction. Lummis's work seeks to understand the relationship between the structure and function of these proteins to aid in the development of novel therapeutic agents. Key publications illustrate her significant contributions to the understanding of the molecular details that relate to receptor function, including studies on the behavior of proline residues within receptor interfaces and the characterization of specific residues that contribute to the function of the 5-HT3 receptor. Her research is vital for developing insights into neurotransmission and therapeutics for various neurological conditions.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.