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Scot Stone is a Professor in the College of Medicine at the University of Saskatchewan, specializing in Biochemistry, Microbiology, and Immunology. He obtained his Ph.D. from the University of Alberta in 1999 and his B.Sc. from the University of Saskatchewan in 1993. His research program focuses on understanding the role of DGAT2 in triacylglycerol synthesis within cells. Triacylglycerols are the major storage form of energy in eukaryotic organisms, and excessive accumulation in adipose tissue leads to obesity, a growing epidemic in Canada. Furthermore, high levels of triacylglycerols in non-adipose tissues can be linked to insulin resistance and type 2 diabetes mellitus, as well as cardiovascular diseases. The enzyme DGAT2, present in the endoplasmic reticulum, catalyzes the synthesis of triacylglycerols and interacts with lipid droplets. Stone's studies aim to address critical questions in triacylglycerol metabolism, providing insights into the molecular mechanisms of triacylglycerol synthesis and storage, with the long-term goal of informing the development of therapies for treating and preventing obesity and related cardiovascular diseases.
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