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Dr. Sean C. Murphy focuses on immune responses to complex infectious diseases and the development of diagnostic tests. His primary research area involves malaria infection in humans and animal models, specifically studying Plasmodium parasites. His lab investigates the complex poly-specific T cell repertoire induced by Plasmodium sporozoites using mouse models of malaria infection. Dr. Murphy aims to identify protective antigens in mice and validate orthologous antigens in human subjects to develop multi-component subunit vaccines targeting pre-erythrocytic stages of malaria infection. These vaccines are intended to accelerate elimination efforts and contribute to the global goal of malaria eradication. Additionally, his lab works on antigen discovery and vaccination tools applicable to a wider range of infectious and autoimmune diseases. He collaborates with the Fred Hutch Cancer Research Center and the Seattle Biomedical Malaria Clinical Trials Center to conduct controlled human malaria infection studies, contributing vital insights into effective malaria drug and vaccine candidates.
University of Washington • Seattle, WA
Teaching and research in the Department of Laboratory Medicine & Pathology.
Seattle Children’s Hospital • Seattle, WA
Overseeing clinical microbiology operations.
Department of Laboratory Medicine & Pathology • University of Washington
Leading malaria diagnostics research.
UW Medical Center - Montlake • University of Washington
Assisting the clinical microbiology laboratory operations.
Standard Graduate School requirements for University of Washington apply to most departments listed unless specified otherwise by the program.