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Sean Ronnekleiv-Kelly is an Assistant Professor in the Department of Surgery at the University of Wisconsin–Madison. His research primarily focuses on understanding how circadian disruption, including factors such as chronic jet lag and genetic modifications of core clock genes, contributes to the development and spread of pancreatic cancer. His initial studies characterized the impact of circadian disruption on the pancreatic transcriptome and lipidome. Notably, he found that chronic jet lag induced significant changes in the core circadian clock, which subsequently altered gene expression within pancreatic metabolic pathways, particularly affecting channel proteins involved in insulin secretion and the expression of pancreatic lipid species. Ronnekleiv-Kelly is working to discern how circadian biology and disruptions to circadian rhythms correlate with metabolic changes in the pancreas, proposing that these disruption-induced metabolic changes may provide a growth advantage to cancer cells in the pancreas.
Department: Department of Computer Sciences