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Sendurai Mani is a Dean's Professor of Translational Oncology and a Professor of Medicine at Brown University's Warren Alpert Medical School. His research focuses on the mechanisms behind metastasis and drug resistance in cancer. He investigates the epithelial-mesenchymal transition (EMT), a process that enhances the migratory and invasive capabilities of cancer cells, allowing them to become metastatic. His work has demonstrated that tumors at metastatic sites often mirror the characteristics of primary tumors, and that EMT provides cancer cells with stem cell-like properties. Mani's lab aims to delineate the molecular mechanisms of EMT that endow cancer cells with metastatic competence and to develop early detection markers for cancer cells exhibiting EMT stem cell properties. Additionally, he is characterizing the interactions between innate and adaptive immune cells and tumor cells during cancer progression using advanced techniques such as single-cell transcriptomics.
Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University • Providence, Rhode Island
Teaching and conducting research in the field of Translational Oncology.
Warren Alpert Medical School • Providence, Rhode Island
Leading initiatives in stem cell research and applications.
Warren Alpert Medical School • Providence, Rhode Island
Overseeing translational research initiatives in various disease areas.
Legorteta Cancer Center, Warren Alpert Medical School • Providence, Rhode Island
Managing translational oncology research efforts.
Department: Department of Economics