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Sergey Ovchinnikov studies protein structure evolution at various scales including environmental, organismal, genomic, structural, and molecular. His research employs phylogenetic inference, protein structure prediction and determination, protein design, deep learning, and energy-based models to tackle evolutionary questions. He aims to develop a unified model of protein evolution, integrating insights from multiple biological perspectives. Ovchinnikov holds the Helen Irwin Sizer Career Development Professorship at MIT, where he contributes to advancing the understanding of how protein structures evolve over time. His collaborative work often intersects with various disciplines, enhancing the academic discourse around protein engineering and evolutionary biology.