Dr. Sergi Regot

Biography

Sergi Regot is an Associate Professor in the Department of Molecular Biology and Genetics at Johns Hopkins University. His research focuses on the fundamental properties of living cells, particularly their extraordinary ability to sense and respond to changing environments. His work has implications in understanding the malfunctioning signaling networks that can lead to severe consequences in higher eukaryotes, such as cancer, diabetes, and autoimmunity. Regot has emphasized the significance of understanding how individual cells utilize signaling networks to integrate information and coordinate collective cell behaviors. In his lab, he adopts a single-cell approach to study the dynamics of signaling networks, combining 3D live-cell imaging, fluorescent biosensors, and optogenetics. Regot's research addresses the stochastic nature of molecular interactions that challenge the traditional understanding of how cells transduce environmental information, often neglected in bulk cell population assays. The lab investigates the origins and consequences of signaling dynamics at the single-cell level, particularly in the context of multicellular interactions that lead to complex functions such as immune response and carcinogenesis. His aim is to shed light on the fundamental principles of cell signaling and multicellularity and their impact on human disease.

Research Interests