Dr. Seth Margolis

Biography

Seth Margolis is an Associate Professor at the Solomon H Snyder Department of Neuroscience, Johns Hopkins University, with a broad background in biochemical, proteomic, and molecular cellular approaches to dissecting protein homeostasis and signaling mechanisms in neuronal biology. His lab focuses on the ubiquitin proteasome pathways and actin cytoskeleton to control the early developmental formation of excitatory synapses in both healthy and diseased brain states. He has conducted significant research on the functions of the ubiquitin ligase UBE3A, especially its role in neural development and its implications for the cognitive disorder Angelman syndrome. His work aims to advance the understanding of protein degradation mechanisms relevant to Alzheimer’s disease. The team has discovered a novel neuronal-specific membrane-associated proteasome complex that influences neuronal signaling, presenting new avenues for research in the field. Long-term, Margolis envisions addressing key questions about the roles and regulation of proteasome-derived signaling peptides in neuronal physiology and behavior.

Research Interests