Dr. Seth Margolis

Biography

Dr. Seth Margolis is an Associate Professor in the Department of Biological Chemistry with a secondary appointment in the Sol Snyder Department of Neuroscience at Johns Hopkins University School of Medicine. His research team focuses on studying protein homeostasis machinery, specifically the control of neuronal function, development, and disease. In 2017, Dr. Margolis's team made significant discoveries regarding a novel neuronal-specific proteasome complex and its role in the production of unique extracellular signaling peptides. He received his undergraduate degree in Biochemistry from the University of Rochester and earned his Ph.D. from Duke University, followed by postdoctoral training in neurobiology at Harvard Medical School. Dr. Margolis joined the faculty at Johns Hopkins in 2011, where he has been actively engaged in advancing the understanding of protein degradation mechanisms relevant to Alzheimer's disease etiology. His extensive expertise includes biochemical, proteomic, molecular, and cellular approaches as well as behavioral studies that dissect signaling mechanisms in neuronal biology.

Research Interests

Experience