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Shannon Sirk is an Assistant Professor in the Department of Bioengineering at the University of Illinois. His research focuses on the engineering of biotherapeutics, an innovative approach that aims to improve health outcomes through protein-based therapeutics, particularly monoclonal antibodies and their derivatives. Recently, his research has expanded to the engineering of cells that act as living therapeutics. This work is critical as it addresses unmet health needs across human, animal, and environmental health. Sirk's research explores the complex ecosystem of human commensal microbes, which play a significant role in health and metabolism. His work aims to optimize the expression and secretion of therapeutic payloads in key commensal species, contributing to the development of safe and effective treatment methods. Sirk also focuses on protein engineering strategies to enhance the functionality and serum half-life of antibody fragments, which are more efficient for bacterial production. In addition to his role at the University of Illinois, he has previously held postdoctoral positions at renowned institutions, including the Scripps Research Institute and Stanford University.
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