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Dr. Sharlene M. Day is a Presidential Professor in the Department of Medicine at the University of Pennsylvania. Her clinical expertise encompasses inherited genetic heart diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, and long QT syndrome channelopathies. Dr. Day leads a research program primarily focused on hypertrophic cardiomyopathy (HCM), a common genetic cardiovascular disease characterized by Mendelian inheritance. Her research combines basic, translational, and clinical science to explore how genetic and non-genetic factors, especially exercise, influence cardiovascular phenotype and clinical outcomes for patients with HCM. She utilizes a variety of resources, including model systems and human heart tissue from genotyped HCM patients, to understand the molecular pathophysiology of HCM. A significant aspect of her research involves studying mutations in the myosin binding protein C (MYBPC3) gene, which harbors a high number of mutations linked to hypertrophic cardiomyopathy. Dr. Day's lab has identified critical regulators within the HSP70 family of molecular chaperones that influence MYBPC3 turnover and aims to explore these pathways as potential therapeutic targets.
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