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Sharlene M. Day, MD, is a Presidential Professor at the University of Pennsylvania's Perelman School of Medicine, specializing in inherited genetic heart diseases. Her clinical expertise encompasses various forms of cardiomyopathy, including hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy, and arrhythmogenic cardiomyopathy. Dr. Day's research is primarily focused on HCM, examining both genetic and non-genetic factors that affect cardiovascular health outcomes. Her work integrates basic and translational clinical science, particularly in understanding the molecular mechanisms underlying this condition. She is actively involved in large multicenter registry clinical trials to explore these factors further. Recently, her research has concentrated on myosin binding protein C (MYBPC3), a gene associated with the majority of mutations linked to HCM. Dr. Day's lab has made significant advancements, identifying critical regulators in the pathophysiology of MYBPC3 and screening compounds that may restore function to affected cardiac cells. She holds a Bachelor of Science degree in Biology from the Massachusetts Institute of Technology and a Doctor of Medicine from New York University School of Medicine. Dr. Day's contributions to her field are reflected in her active engagement in research and clinical practice.
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