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Shawn Li is a faculty member at Western University, actively researching the molecular epigenetic basis of cancer. His work primarily involves developing protein and peptide-based diagnostic and therapeutic agents aimed at cancer treatment. By employing an integral approach that combines molecular, cellular, structural, and proteomic insights, his lab seeks to achieve a comprehensive understanding of how proteins interact and transduce regulatory signals that lead to aberrant changes in cell signaling and contribute to complex human diseases, particularly cancer. The lab’s major research focuses include investigating the roles of post-translational modifications (PTM), such as the phosphorylation of tyrosine, serine, threonine, and the methylation of lysine and arginine, in regulating critical cellular processes such as proliferation, differentiation, migration, apoptosis, and the DNA damage response. The dysregulation of protein phosphorylation and methylation is closely linked to tumorigenesis and cancer metastasis, which drives the lab's commitment to developing novel diagnostic and therapeutic strategies that target PTMs and their modifying enzymes.
Western University • London, Ontario, Canada
Engaged in research concerning the molecular mechanisms involved in cancer and the development of therapeutic strategies.
Streams include Archaeology and Bioarchaeology, and Sociocultural Anthropology.