Dr. Sheela Abraham

Biography

Dr. Sheela Abraham is an Associate Professor at Queen's University in the School of Medicine, specializing in Biomedical Molecular Sciences. She completed her Ph.D. at the University of British Columbia, where she focused on lipid membrane nanoparticles for cancer therapeutics. Her work led to the FDA-approved liposomal formulation, Vyxeos™, which significantly improves survival rates in acute myeloid leukaemia (AML) patients. Dr. Abraham's postdoctoral research focused on chronic myeloid leukaemia (CML) and involved advanced techniques in cellular biology. Her research interests lie in understanding the signaling pathways essential for the maintenance and development of normal and cancer stem cells, with a focus on the role of extracellular vesicles in communication within the bone marrow microenvironment. Dr. Abraham has published extensively in high-impact journals on topics including the biology of CML stem cells and the therapeutic implications of targeting these cells. She employs a diverse range of methods such as mass spectrometry, RNA sequencing, and bioinformatics in her studies.

Research Interests