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Dr. Sheila Drover is an Associate Professor in Immunology at Memorial University of Newfoundland. Her research focuses on understanding the role of immune markers in conditions such as breast cancer. The Drover laboratory has made significant contributions by revealing that tumor cells in breast cancer can express various types of HLA molecules and influence the immune response against these tumors. Studies conducted in her lab demonstrate that tumor cells' escape from immune destruction is often mediated by the upregulation of inhibitory checkpoint molecules such as PD-1 and LAG3. The lab is currently researching mechanisms that deregulate IFN-γ and HLA pathways in HER2-positive breast cancer, and exploring immunomodulation of HLA-PD-L1 interactions using small kinase inhibitors. Dr. Drover's work has garnered funding from several prestigious organizations including the Canadian Breast Cancer Foundation and the Medical Research Council.
Department of Business Administration (MBA program)