Dr. Shivani Srivastava

Biography

Shivani Srivastava earned her Ph.D. in Biochemistry from Banaras Hindu University, India, where her doctoral research focused on the molecular mechanisms of diabetes, with a particular emphasis on pancreatic β-cell and intestinal adaptation, incretin hormones, and the phytotherapeutic modulation of metabolic pathways. Her work provided rigorous training in metabolic endocrine biology and established a long-standing interest in understanding the cellular stress responses that contribute to metabolic disease. In March 2020, she moved to the United States to further expand her research training, initially working at Ohio State University and UCLA, where she investigated mouse models of cardiovascular metabolic disease. These experiences strengthened her technical expertise in in vivo metabolic phenotyping, vascular pathology, inflammatory signaling, and cardiometabolic stress responses, thereby deepening her understanding of the mechanistic links between metabolic dysregulation and cardiovascular disease. Currently, at Yale University, her research focuses on rare skeletal metabolic disorders, including Hutchinson–Gilford progeria syndrome and ENPP1-associated obesity, as well as the ossification of the posterior longitudinal ligament. Using genetically engineered mouse models and in vitro approaches, her work examines the roles of metabolic enzymes and disease-associated genetic variants in regulating skeletal mineralization, adipose biology, and systemic metabolic homeostasis. Her studies aim to define disease mechanisms and evaluate therapeutic strategies in preclinical models, integrating disease-relevant preclinical models with mechanistic studies to bridge basic science and clinical translation in fields such as bone disease, metabolic diseases (including diabetes and obesity), and cardiovascular disease.

Research Interests