Dr. Shukti Chakravarti

Biography

Shukti Chakravarti's research focuses on the extracellular matrix (ECM) and its interactions with cells, particularly in the context of inflammation and tissue repair. Her laboratory specializes in studying the cornea, an ECM-rich tissue that serves as a protective barrier and refractive structure of the eye. Chakravarti has made significant contributions to understanding the role of the proteoglycan lumican in collagen fibril assembly and its implications in ocular diseases such as keratoconus. Specifically, her studies have shown that lumican-deficient mice exhibit disorganized collagen fibrils, resulting in excessive light backscatter and corneal clouding. Her work extends to the interaction of proteoglycans with immune cells, altering vesicular trafficking and influencing inflammatory signaling pathways. Through her research, she aims to uncover the dynamics of ECM remodeling and its regulatory effects on immune responses, which is vital for advancing therapeutic strategies in ocular health.

Research Interests

Experience