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Shuo Han is an Assistant Professor in the Department of Biochemistry at Duke University. His research primarily focuses on understanding the interplay between human gut microbiota and host aging. The human gut microbiota is composed of trillions of microorganisms that encode diverse metabolic pathways impacting gastrointestinal health and systemic immunity. Research indicates that microbiota diversity decreases with age, suggesting that changes in gut microbial composition may affect host biological processes. Through fecal microbiota transplantation in healthy mice, his work has shown improved healthspan and lifespan in progeroid mouse models, highlighting the mechanistic roles of gut bacterial communities in modulating host aging. Han employs metabolomics, microbiology, and molecular genetics to investigate how gut microbiota regulates host physiology at multiple levels, aiming to identify novel mechanisms of gut microbe-host interactions to develop interventions that ameliorate age-associated health decline in mammalian hosts.
Duke University • Durham, NC
Faculty member focusing on microbiota and aging research.
Department of Biomedical Engineering (MS program)