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Siew Yeen Chai has a 20-year research career focusing on neurodegenerative diseases, particularly Alzheimer's disease, motivated by personal family experiences. Her research centers on insulin-regulated aminopeptidase (IRAP), where her team discovered that blocking this enzyme can enhance memory performance in neurodegenerative contexts. At Monash University, she collaborates with the Howard Florey Institute and other researchers to employ computer-based drug screening strategies aimed at identifying IRAP inhibitors from a library of 1.5 million compounds. These inhibitors showed promise in mouse models of Alzheimer's, leading to improved memory and reduced amyloid plaque deposition. Chai has published 128 research papers, received seven patents, and her work contributes to the UN Sustainable Development Goals, particularly in health and well-being. She is also an Honorary Research Fellow at the Florey Institute of Neuroscience and Mental Health.
Monash University • Clayton, Australia
Conducting research in neurodegenerative diseases and teaching.
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