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Simon Daff is a Lecturer in Bioinorganic Chemistry at the University of Edinburgh. His research focuses on understanding and controlling the mechanisms of redox enzymes. Specifically, his work encompasses mammalian synthases, which are large multidomain enzymes involved in the regulation of blood flow, blood pressure, immune response, and nerve signalling. Simon aims to understand the mechanisms of action at the molecular level to find new ways to control enzymatic activity through inhibition and activation. Additionally, he studies heme-dependent monooxygenases, which serve as powerful catalysts that can insert oxygen atoms into otherwise unreactive molecules. By examining the energetics of these processes and remodelling enzymes to trap reactive intermediates, he seeks to gain control over their function. Moreover, Simon leverages robust electron transfer proteins to build protein-based electron transfer wires for enzyme electrochemistry, facilitating the construction of novel electroactive enzymes. His research employs a combination of specialist techniques, including rapid-reaction kinetics, protein engineering, chemical genetic manipulation, spectroscopy, electrochemistry, and X-ray crystallography.
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