Dr. Simon Langdon

Biography

Simon Langdon is a Reader in Pathology at the University of Edinburgh, affiliated with the Cancer Research UK Scotland Centre and the Institute of Genetics and Cancer. Dr. Langdon's research focuses on the cellular signaling pathways that regulate cancer growth, survival, differentiation, and invasion. His current projects aim to improve treatments for ovarian and breast cancers by developing therapeutic strategies that target the estrogen receptor, erbB, and DNA repair-related signaling pathways. Furthermore, his work investigates the unique dependencies of individual cancers on specific signaling pathways, seeking to establish connections between pathway activation and cellular outcomes such as growth, apoptosis, and migration. He is also involved in evaluating new inhibitors using preclinical models and is exploring strategies to enhance the efficacy of radiotherapy in breast cancer, particularly in hypoxic tumor regions. Dr. Langdon employs experimental cancer models and systems biology approaches to develop predictive models of cancer signaling that can integrate data from primary human cancers, ultimately identifying candidate targets and dynamic biomarkers for clinical trials.

Research Interests

Experience