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Simon Sharpe obtained a BSc in Cell Biology and Biochemistry from Memorial University of Newfoundland in 1997 and completed his PhD in Biochemistry at the University of Western Ontario in 2002. He then joined Robert Tycko’s group at the NIH as a postdoctoral fellow, where he used solid-state NMR to determine the structures of peptide-antibody complexes and integral membrane proteins involved in HIV-1 pathogenesis. Dr. Sharpe joined the Department of Biochemistry at the Hospital for Sick Children in 2006. His research interests encompass self-assembling proteins, amyloid formation related to degenerative diseases, and protein-membrane interactions. His program focuses on providing molecular-level understanding of macromolecular assemblies that play crucial roles in human health and disease. He employs solid-state NMR as a primary tool and incorporates a variety of biophysical methods to investigate structural and dynamic properties of amyloid fibrils and large macromolecular complexes. Aiming to elucidate the molecular basis of amyloid assembly and cytotoxicity, he also explores the assembly and structure of elastomeric proteins and the interactions of viral membrane proteins with the host cell immune response.
Hospital for Sick Children • Toronto, Ontario, Canada
Conducting research and teaching in the Department of Biochemistry, focusing on protein-membrane interactions and macromolecular assemblies.
Department of Sociology