Dr. Slavica Tudzarova Trajkovska

Biography

Slavica Tudzarova-Trajkovska is an Adjunct Assistant Professor in the Department of Medicine, specializing in Endocrinology. Her research focuses on the mechanisms regulating DNA replication initiation, particularly its relationship with cell proliferation and metabolism. She investigates the roles of CDK2 and CDC7 kinases in cell cycle checkpoints and their implications in cancer biology. Tudzarova-Trajkovska's work has elucidated how metabolic signals influence G1-S transition and the activation of DNA replication origins. Her studies have revealed critical interactions between glycolysis and cell cycle regulation, emphasizing the importance of metabolic adaptations in both normal and cancer cells. She utilizes high-resolution mass spectrometry proteomics to dissect the molecular architecture of the DNA replication machinery, emphasizing the differences in normal and malignant cellular responses to genotoxic stress. Tudzarova-Trajkovska is dedicated to understanding these complex interactions to identify potential therapeutic targets in cancer treatment, particularly in the context of CDC7 inhibition. Her publications reflect her expertise in molecular biology, cell cycle regulation, and metabolic signaling, contributing significantly to the fields of endocrinology and cancer research.

Research Interests

Experience