Dr. Solomon Snyder

Biography

Solomon H. Snyder is a Professor Emeritus of Neuroscience at Johns Hopkins University School of Medicine. His research focuses on the molecular mechanisms of neurotransmission and the role of atypical neurotransmitters, particularly gasotransmitters such as nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). He has extensively studied the signaling pathways affected by these molecules, contributing significantly to our understanding of their physiological and pathological roles in the nervous system. Snyder's work led to the discovery of D-serine as a novel neurotransmitter and its interaction with NMDA receptors. He has identified critical mechanisms related to diseases like Huntington's Disease, highlighting the impact of specific mutations on neurotransmitter systems. His lab has characterized pathways involving enzymatic processes influenced by various stimuli, including physiological parameters and drug interactions. Snyder's research also delves into the role of proteins such as GAPDH in cellular signaling and the effects of nitrosylation, which modulates enzyme activity in response to oxidative stress. His pioneering studies have opened new avenues for therapeutic strategies for neurological disorders and addictions.

Research Interests

Experience