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The Abraham laboratory is focused on developing innovative approaches to curb microbial infections through the study of molecular interactions occurring between pathogenic bacteria and prominent immune epithelial cells. The research emphasizes the crosstalk between bacteria and host cells, which influences the outcome of infections, determining whether they are swiftly cleared or result in severe pathology. Significant research areas include elucidating the role of mast cells in modulating immune responses to microbes, revealing their essential role as sentinels in bacterial and viral infections. Current investigations are exploring the molecular and cellular aspects by which mast cells mediate their immunomodulatory function and developing mast cell-targeted strategies to enhance immunity while diminishing the pathological consequences of infections. The laboratory examines the cross-talk between distinct infectious agents such as Uropathogenic E. coli, Salmonella typhimurium, and Yersinia pestis with the immune system, uncovering novel innate host defense activities. These findings are aimed at facilitating the design of innovative strategies to combat pathogens by selectively enhancing the host’s immune response while minimizing harmful side effects.
Duke University • Durham, NC
Roles include leading research initiatives in the Department of Pathology.
Washington University St. Louis • St. Louis, MO
Oversaw clinical operations and research related to pathology.
Washington University St. Louis • St. Louis, MO
Engaged in teaching and research in pathology.
Washington University St. Louis • St. Louis, MO
Assisted in administrative and clinical responsibilities.
University of Tennessee, Knoxville • Knoxville, TN
Conducted research and taught in microbiology.
Department of Biomedical Engineering (MS program)