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Sophia Davidson studies the interplay of genetics, inflammation, and neurodevelopment. She began her research career at the University of Newcastle (Australia), investigating the body's inflammatory response to respiratory infections. After completing her PhD, she moved to the United Kingdom to study at the Francis Crick Research Institute in London, where her research focused on how genetics influence the body's inflammatory response to the influenza virus. Unexpectedly, she discovered that certain aspects of the anti-viral inflammatory response can exacerbate disease. This discovery progressed to influencing clinical trials related to influenza virus and COVID-19. Having a keen interest in the relationship between genetics and inflammation, Davidson joined the lab of Professor Seth Masters in 2016 (WEHI) to work on inflammatory diseases caused by genetic mutations. Her team identified novel pathways of inflammatory signaling that are triggered by genetic mutations disrupting cell homeostasis. Davidson's research has revealed new targets for drug development and aims to design treatment regimens for patients with rare diseases. Her work includes studying monogenic autoinflammatory diseases to explore the role of inflammation in neurodevelopmental disorders, using genetic editing, induced pluripotent stem cell models, and super resolution imaging to investigate the inflammatory pathways activated in these disorders.
Hudson Institute - Centre for Innate Immunity and Infectious Disease • Australia
Research in understanding the interplay of genetics, inflammation, and neurodevelopment.
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