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Squire J. Booker is the Penn Integrates Knowledge University Professor and a Howard Hughes Medical Institute Investigator at the University of Pennsylvania. His research focuses on the elucidation of chemical mechanisms employed by enzymes that contain iron-sulfur clusters to catalyze chemical reactions. The projects in the Booker Lab notably include members of the Radical S-adenosylmethionine Superfamily, a diverse group of enzymes that utilize radical chemistry to catalyze various transformations related to post-transcriptional and post-translational modifications, cofactor biosynthesis, and secondary metabolite production. Utilizing a combination of biochemical, analytical, structural, and spectroscopic techniques, the lab aims to characterize intricate and fascinating reaction mechanisms with the objective of enhancing the understanding of applications in human health and disease.
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