Dr. Srikant Rangaraju

Biography

Srikant Rangaraju specializes in vascular neurology and serves as an Associate Professor at Yale School of Medicine. His research focuses on studying the immune-mediated mechanisms of neurodegeneration following ischemic brain injuries, utilizing preclinical mouse models and multi-omics approaches to assess molecular alterations in different neuronal and glial cell types. Dr. Rangaraju is actively involved in clinical research on stroke, particularly in exploring clinical trials and studies regarding post-stroke prognosis and the role of plasma-based protein biomarkers for cryptogenic stroke risk stratification. He provides comprehensive clinical care to stroke patients in both inpatient and outpatient settings. Since establishing the Rangaraju Lab in 2016, which has been funded by the NIH, the group has identified promising therapeutic targets, including the potassium channel Kv1.3, which is upregulated in specific pro-inflammatory microglia/macrophages. The lab has focused on manipulating Kv1.3 to understand its regulatory impact on neuroinflammatory responses associated with neurodegenerative diseases. Their novel approaches include developing methods for analyzing protein-level mechanisms within unique brain cell types, with an emphasis on therapeutic target identification for disease modification.

Research Interests