Dr. Steffen Wolf

Biography

Steffen Wolf's main research interests lie at the intersection of biological physics and biomolecular dynamics. He focuses on understanding biomolecular systems by utilizing the principles of physics and chemistry to rationalize protein functional motion and dynamics. His work explores intra- and inter-protein signal transduction, as well as protein-ligand binding predictions over physiologically relevant timescales. He investigates nonequilibrium systems and employs multiscale molecular dynamics simulations, including quantum mechanics and molecular mechanics approaches. His research incorporates various methodologies, such as nonequilibrium statistical mechanics, to analyze dynamic effects. Notable developments in his research include nonequilibrium principal component analysis (NEQ-PCA) and dissipation-corrected targeted molecular dynamics (dcTMD). He emphasizes collaboration with experimentalists, particularly in areas like time-resolved FTIR spectroscopy and single molecule FRET spectroscopy, to validate theoretical predictions and extend the capabilities of molecular dynamics simulations.

Research Interests