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Stéphane Angers’ research focuses on molecular mechanisms underlying signal transduction events activated by Wnt and Hedgehog families of secreted growth factors. Angers is developing novel therapeutics to target pathways for cancer treatment. His research addresses processes that control self-renewal and proliferation of stem cells, which are likely involved in the initiation and progression of cancers. The Wnt and Hedgehog families play fundamental roles in embryonic development and adult tissue homeostasis. Angers’ lab employs a combination of patient-derived stem cells, organoids, and animal models of disease to investigate Wnt and Hedgehog pathways in normal human and disease contexts. The lab utilizes genome-wide CRISPR-Cas9 functional screens performed in patient-derived cancer stem cells to characterize essential genes for tumor growth. Angers Lab aims to identify novel therapies that modulate the activity of Wnt and Hedgehog pathways, leading to potential new cancer therapies while also exploring the pathways' roles in enhancing tissue repair in regenerative medicine.
Department of Sociology