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Stephen Adam has a long career dedicated to understanding the mechanisms that establish and maintain cellular compartments. He received his PhD from Northwestern University under the supervision of Gideon Dreyfuss, followed by postdoctoral fellowships with Larry Gerace at Johns Hopkins University School of Medicine and the Research Institute of Scripps Clinic as a Damon Runyon/Walter Winchell Fellow. His early postdoctoral studies initiated projects into the mechanisms of nuclear protein transport. As an associate professor at Feinberg, he has continued his focus on nuclear protein transport, notably identifying proteins that target nuclear localization sequences required for transport from the cytoplasm to the nucleus. Since the mid-2000s, his focus has broadened to study the assembly and biochemical roles of intermediate filament proteins, particularly nuclear lamins and cytoplasmic vimentin. His research also explores the post-translational modification of proteins and their effects on assembly, structure, and the interactions of cellular factors. He employs mammalian cell models to investigate Hutchinson-Gilford Progeria Syndrome and the roles of nuclear lamin defects in epithelial-mesenchymal transition, development, and metastasis.
Administered by The Graduate School; focuses on Biomechanics, Imaging, Biomaterials, and Regenerative Medicine.